The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may perhaps bring about an increase in methadone plasma concentrations, which could result in possibly lethal respiratory despair. Also, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally end